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Kate Scheuer

Research on Circadian Clock Biology and Simplifying Syntax in Evolvix.

Kate Scheuer PortraitMy interests include circadian clocks, mental health, psychiatric medication, and community health programs catering to under-served populations. When not at work, you can find me running through local parks, attending rock concerts, or playing Magic: the Gathering.

 

Education

B.S. in Psychology and Spanish, 2014

Honors in Liberal Arts

University of Wisconsin-Madison

 

Research

Tiny fruit flies are an important model system for various human conditions related to the timing of the sleep-wake cycle. The gene regulatory network of the circadian clock allows fruit flies to measure internally which time of the day it is and to prepare accordingly. Since these molecular circuits of fruit flies are very similar to those in mice and humans, we have learned much about human chrono-biology from studying fruit flies first.


Using the latest published research, I am developing a computational model of the Drosophila melanogaster circadian clock that integrates everything we know about it, up to the latest experiments. My model is particularly exploring stochastic effects, which are often ignored. I also aim to represent incomplete knowledge and inconclusive evidence in a way that can enable computers to use that information. My model is being written and simulated using Evolvix, a new, user-friendly model-description language that is being developed in the lab. I am also regularly part of discussions aiming to improve the usability and clarity of syntax in Evolvix.

 

Awards

Welton Honors Summer Sophomore Apprenticeship Research Grant for undergraduate research at the University of Wisconsin-Madison, June 2012 - August 2012

 

Circadian Clock Research

  1. Hotz, Alyssa, Scheuer, Kate, and Loewe, Laurence (2016) "Clarifying Long-term Memory Formation in Drosophila melanogaster by Integrating the Influences of the Notch and Wingless Signaling Pathways on CREB and ß-Catenin", Poster at the Undergraduate Symposium, UW-Madison, 2016, April 14. (PDF).
  2. Waters, Noah, Scheuer, Kate, and Loewe, Laurence (2016) "The Role of Clockwork Orange and MicroRNA in the Drosophila melanogaster Circadian Clock", Poster at the Undergraduate Symposium, UW-Madison, 2016, April 14. (PDF).
  3. Nusbaum, Claire, Scheuer, Kate, and Loewe, Laurence (2016) "Effects of dVMAT Expression on Depression and the Circadian Clock in Drosophila melanogaster", Poster at the Undergraduate Symposium, UW-Madison, 2016, April 14. (PDF).
  4. Nolan, Erik with the Loewe Lab (Scheuer, Kate and Loewe, Laurence) (2016) "A Proposed Role for Melatonin: Circadian Regulation in Drosophila melanogaster", Poster at the Undergraduate Symposium, UW-Madison, 2016, April 14. (PDF).
  5. Waters, Noah, Scheuer, Kate, and Loewe, Laurence (2015) "The Function of Evening and Morning Oscillators in the Circadian Clock", Poster at the Undergraduate Research Scholars presentation session, UW-Madison, 2015, December 9. (PDF).
  6. Nusbaum, Claire, Scheuer, Kate, and Loewe, Laurence (2015) "Influence of bipolar disorder drug treatments (lithium, risperidone and fluoxetine) on the circadian protein SGG in Drosophila melanogaster", Poster at the Intro Bio 152 UG Symposium, Union South, UW-Madison, 2015 Dec 8. (PDF).
  7. Scheuer, Kate, and Loewe, Laurence (2015) "Evidence-driven Hypothesis Modeling of the Drosophila melanogaster Circadian Clock", Poster presented at the Workshop on Evolutionary Systems Biology & Modeling, UW-Madison, WI, 2015 Aug 25. (PDF).
  8. Tucker, Devanie, Scheuer, Kate, Loewe, Laurence (2015) "Circadian Clock Synchronization and the Roles of PDF, cAMP, and PKA in Drosophila melanogaster", Poster at the Intro Bio 152 UG Symposium, Union South, UW-Madison, 2015 May 5. (PDF).
  9. Hotz, Alyssa, Scheuer, Kate, Loewe, Laurence (2015) "Combinatorial Complexity and CLOCK Phosphorylation in the Circadian Clock of Drosophila melanogaster", Poster at the Undergraduate Symposium, UW-Madison, 2015, April 16. (PDF).
  10. Hotz, Alyssa, Scheuer, Kate & Loewe, Laurence (2014) "The Phosphorylation Process of CLOCK in the Circadian Clock of Drosophila melanogaster", Poster at the Intro Bio 152 UG Symposium, Union South, UW-Madison, 2014 Dec 9. (PDF).
  11. Scheuer, Kate and Loewe, Laurence (2013) "Possible Applications for an Updated Model of the Drosophila melanogaster Circadian Clock", Poster presented at the Undergraduate Symposium, Union South, UW-Madison, 2013 April 18 (first presented), 2014 Aug 05 (updated). (PDF).
  12. Dresel, Jerdon, Scheuer, Kate, Loewe, Laurence (2013) "Interactions of the F Box Protein Jetlag in Circadian Clocks, Undergraduate Symposium", Poster at the Union South, UW-Madison, 2013 April 18 (first presented), 2015 Aug 25 (updated). (PDF).
  13. Scheuer, Kate (2012) "Biological Modeling and Language Development Using the Circadian Clock of Drosophila melanogaster", Presentation at the Welton Honors Summer Sophomore Apprenticeship Retreat, 2012 July 25. (PDF).
  14. Scheuer, Kate and Loewe, Laurence (2012) "A Molecular Systems Biology Model of the Circadian Clock of Drosophila melanogaster", Poster presented at the Undergraduate Symposium, Union South, UW-Madison, 2012 April 18 (first presented), 2013 Jan 7 (updated). (PDF).

 

Contributions to Simplifying Syntax in Evolvix

  1. Loewe, Laurence, Seth A. Keel, Kurt Ehlert, Tanner Engbretson, Jacob Goldfinger, Kate Scheuer, and Iratxo Flores-Lorka  (2015) "User manual for Evolvix 0.3.1", http://evolvix.org/download
  2. Loewe, Laurence, Seth A. Keel, Kurt Ehlert, Iratxo Flores-Lorka, Kate Scheuer (2014) "Maximizing Expressivity in Evolvix", Poster at the NSF Cyberbridges Workshop, Arlington, VA,  2014 June 1.
  3. Loewe, Laurence, Seth A. Keel, Kurt Ehlert, Iratxo Flores-Lorka, Kate Scheuer (2014) "Why evolutionary systems biology needs a model description language to cut costly coding complexity", Poster at the Society for Molecular Biology and Evolution Conference, SMBE, Puerto Rico, 2014 June 9.
  4. Loewe, Laurence, Seth A. Keel, Kurt Ehlert, Iratxo Flores-Lorka, Kate Scheuer (2014) "Simulations of Ecology and Evolution in the Evolvix model description language", Poster at the Population Genetics Midwest Meeting, Chicago, IL, 2014 July 19. 
  5. Loewe, Laurence, Seth A. Keel, Kurt Ehlert, Iratxo Flores-Lorka, Kate Scheuer (2014) "Simulating Metabolic Networks with the Evolvix model description language", Poster at the HLSC UW-Madison, MIR Metabolomics Meeting, UW-Madison, 2014 Aug 05. 

 

Other publication

Scheuer, Kate (2013) "Banana Republic as an Epithet and as a Clothing Store". Concientización: A Journal of Chican@ & Latin@ Experience and Thought 8, No. 2: 52-56.